Graphene is an exceptional class of 2-D carbon material with excellent physicochemical properties such as high surface area (2630 m2 g−1), better electrical/thermal conductivity (∼5000 W m−1 K−1), high mobility of charge carrier (200,000 cm2 V−1 s−1), etc. Though a number of methods have been developed for synthesis of graphene, the wet chemical process is an efficient one for the scalable production of both graphene and functionalized graphene. Moreover, the ease of chemical modification of graphene’s surface make it suitable to employ in a broad range of applications, from energy to biomedical. Among other high-performance applications, the graphene-based materials have drawn substantial attention, both for the adsorption and removal of several environmental and health-threatening pollutants from the air. This chapter elaborately discusses the synthesis, functionalization, and composite preparation of graphene for the removal of toxic pollutants from air. It starts with an overview of different air pollutants and materials used for their filtration. Then a detailed discussion on the synthesis, physicochemical properties, and functionalization of graphene followed by its application towards the air filtration (for removal of CO2, SO2, aerogels, particulate matters, alkanes, etc.) will be presented. The chapter will conclude with a brief summary and perspective on the functionalized graphene material for air filtration.